St Helens unbeaten start to the season is over after a 28-20 defeat at home to Leeds Rhinos.
Two tries from Ash Handley as well as tries for Anthony Mullally, Richie Myler, who also added a goal, and Matt Parcell won the game for the Rhinos in a thriller.
Two tries for Ben Barba and another for Adam Swift kept the Saints in it, but they lose their first game of the season.
Saints remain top of the Super League but they could have their lead at the top wiped out if both Wakefield Trinity beat Widnes Vikings and Wigan Warriors beat Castleford Tigers. They travel to Hull KR next week.
As for Leeds, they go up to fourth in the Super League table, just two points behind St Helens. They host Castleford Tigers at Elland Road next Friday.
Elsewhere, Salford Red Devils claimed a second win of the season as they beat Hull FC at the AJ Bell Stadium.
Tries for Ben Nakubuwai, Jack Littlejohn, Robert Lui, who also added four goals, and Greg Johnson claimed the big win for the Red Devils.
Dean Haldey’s solitary was all Hull FC could bring in reply in the week that saw them lose Liam Watts to Castleford Tigers.
It was a welcome victory for the Red Devils, who have struggled so far to live up to the heights of last season. They are 10th in the Super League and they travel to Widnes next Thursday.
As for Hull FC, it has been a bad week and this defeat surely raises more questions than it answers. They host Catalans Dragons next Friday.