Hull FC and Catalans Dragons will both be looking for an advantage in the race for the playoffs.
The two teams lie in third and sixth respectively
The home side come into the game having won four of their last five games, although that defeat was a chastening 62-16 defeat at St Helens.
As for the Dragons, they have won two of their last three games, including an impressive 39-6 away win in the capital against London Broncos.
The Black and Whites have made five changes coming into this one with Marc Snyed, Albert Kelly, Carlos Tuimavave, Dean Hadley and Danny Washbrook all having to drop out through injury.
In come senior members Mark Minichello and Jordan Thompson as well as young players Levy Nzoungou, Liam Harris and Kieran Buchanan. It should make for an experimental side.
The Dragons themselves make four changes to the squad that was beaten at St Helens last week with Fouad Yaha, Arthur Romano, Lucas Albert and Lambert Belmas coming into the squad as David Mead, Mickael Simon and Kenny Edwards are all ruled out with concussion. Benjamin Garcia is also out.
Hull will be hoping for a repeat of last time they faced off against each other as they won 31-30 in Perpignan.
The game kicks off at 7.30pm.