Toronto Wolfpack and Bradford Bulls take centre stage as their game will be on Sky Sports, live from Canada.
The Wolfpack are currently leading the way in the Championship with just one defeat coming from their opening 12 games, their only defeat came against second placed Toulouse.
Bradford have also had a good start to the season as they adapt to life back in the Championship, currently lying in fourth position with eight wins from a possible 12.
The game is set to be a great advert for the Championship, so make sure you watch it if you can.
Before that, second placed Toulouse will hope to keep the pressure on as they travel to Dewsbury Rams.
Toulouse, along with the Wolfpack have been flying the flag for expansion clubs and leading the way for the rest of the Championship.
Their incredible home form, paired with ever improving away form, is proving to be a deadly combination as they compete for a Super League spot.
As for Dewsbury, they have not had the best of starts with just three wins of their first 11 fixtures, but claimed a brilliant win last week at a resurgent Widnes Vikings side, and will be hoping to build on this.
It should make for a brilliant game, it kicks off at 3pm in Dewsbury.
Then moving on to Sunday, which is the main day, where there are five fixtures.
The big one is Matt Calland’s first game in charge of Rochdale Hornets as they welcome Featherstone Rovers at Spotland Stadium. Calland managed Halifax to a 2010 Grand Final win over Rovers in Golden Point.
There will also be a chance to help the Danny Jones Defibrillator Fund by buying 100 years of Welsh Rugby League, available at the Halifax Club Shop at The Shay prior to Halifax’s game against Barrow Raiders.
Both sides are looking to shake off disappointing starts by their standards. Barrow have only won one from 12 and Halifax have a 50/50 record so far with six wins and six defeats.
There is also a local derby as Swinton Lions take on Widnes Vikings.
The Vikings have had a difficult year to date, with financial difficulties not just threatening to derail the season, but also the clubs future. However, the clubs short term future has been secured and they are starting to move forward.
Without their 12 point deduction, the Vikings would be in fifth place in the Championship.
The Lions have had another tough season and have won just two games from a possible 12 so far.
There is also a match which could have big implications in the race for the Super League as Leigh Centurions welcome Sheffield Eagles to Leigh Sports Village.
Both teams lie in fifth and third respectively after solid starts to the season, and the winner will no doubt be in a better position to plough forward and challenge Toronto and Toulouse.
Finally, there is a North vs. West Yorkshire derby as York City Knights welcome Batley Bulldogs to Bootham Crescent.
York have made a solid start to the season with seven wins out of 11 in their first season in the Second Division since 2013.
As for Batley, they have had a slower start to the season, claiming four wins from a possible 12 games, and will want to alleviate this form soon to avoid any relegation worries.
Saturday 4th May
Dewsbury Rams vs. Toulouse 3pm
Toronto Wolfpack vs. Bradford Bulls 6pm Live on Sky Sports
Halifax vs. Barrow Raiders 3pm
Leigh Centurions vs. Sheffield Eagles 3pm
Rochdale Hornets vs. Featherstone Rovers 3pm
Swinton Lions vs. Widnes Vikings 3pm
York City Knights vs. Batley Bulldogs 3pm