Leeds Rhinos face Castleford Tigers in their rearranged fixture at Headingley.
The match was supposed to take place a few weeks ago, but the Tigers were forced to rearrange after positive tests at the club, leaving Hull FC to step in at the last minute.
The Rhinos were much rotated against St Helens on Friday, and fell to a 40-8 defeat.
Castleford picked up only their second win since lockdown on Thursday, as they beat Hull KR.
The match kicks off at 7.45pm and the referee will be Tom Grant.
Richard Agar has welcomed back a number of big personalities for this West Yorkshire derby.
Tom Briscoe, Konrad Hurrell, Ash Handley, Luke Gale, Kruise Leeming, Matt Prior, Alex Mellor, Rhyse Martin and Liam Sutcliffe return to the 21-man-squad after being rested against St Helens.
They replace Rhys Evans, Callum McLelland, Sam Walters, Jarrod O’Connor, Jack Broadbent, Corey Hall, Liam Tindall, James Harrison and Levi Edwards.
The Tigers have also made seven changes to the side that beat Hull KR.
They welcome back Liam Watts, Oliver Holmes, James Clare, Matt Cook, Tyla Hepi and Gareth O’Brien. Academy player Cain Robb could also make his debut.
They replace Grant Millington, Adam Milner, Nathan Massey, Jacques O’Neill, Brad Martin, Bailey Hodgson and Jack Sanderson.