Hull FC and Hull KR will do battle for the second time this year at the Totally Wicked Stadium.
They met in Round Two in 2020, with the Black and Whites taking the spoils 25-12.
Hull will be hoping a week off has done them good, after their match with Catalans Dragons was postponed.
They won their last game 48-6 against Castleford Tigers.
While Hull KR will be hoping for a reaction after their heavy defeat at Wakefield Trinity.
The game kicks off at 7.45pm.
Hull KR have made four changes to the side that lost at Wakefield.
They welcome back Matt Parcell, Weller Hauraki, Kane Linnett and Matty Storton.
Meanwhile, Dan Murray, Ryan Brierley, Kyle Trout and Jamie Ellis are all missing for the Robins.
Meanwhile, Hull FC make three changes to the side that beat Castleford last time out.
Jamie Shaul and Albert Kelly drop out because of injury, while Masi Matongo also drops out.
Josh Jones is included for the first time since testing positive for COVID-19 back in August.
He joins Scott Taylor and Jordan Lane in getting included.