Table
| Position | Team | Played | Won | Draw | Loss | Points For | Points Against | Points Difference | Points Percentage |
| 1 | Toulouse | 12 | 12 | 0 | 0 | 556 | 106 | 477.36 | 100 |
| 2 | Featherstone Rovers | 17 | 16 | 0 | 1 | 715 | 222 | 322.07 | 88.23 |
| 3 | Halifax Panthers | 17 | 12 | 0 | 5 | 442 | 257 | 171.98 | 70.59 |
| 4 | Bradford Bulls | 16 | 11 | 0 | 5 | 441 | 377 | 116.98 | 68.75 |
| 5 | Batley Bulldogs | 18 | 12 | 0 | 6 | 511 | 348 | 146.84 | 66.67 |
| 6 | London Broncos | 16 | 9 | 1 | 6 | 426 | 455 | 93.63 | 53.13 |
| 7 | Whitehaven | 18 | 8 | 1 | 9 | 361 | 476 | 75.84 | 47.22 |
| 8 | York City Knights | 17 | 7 | 0 | 10 | 421 | 403 | 104.47 | 41.18 |
| 9 | Sheffield Eagles | 16 | 5 | 3 | 8 | 350 | 487 | 71.87 | 40.63 |
| 10 | Widnes Vikings | 17 | 6 | 1 | 10 | 390 | 441 | 88.44 | 38.23 |
| 11 | Newcastle Thunder | 16 | 5 | 1 | 10 | 322 | 470 | 68.51 | 34.38 |
| 12 | Dewsbury Rams | 17 | 5 | 1 | 11 | 262 | 507 | 51.68 | 32.35 |
| 13 | Oldham | 17 | 2 | 1 | 14 | 256 | 579 | 44.21 | 14.71 |
| 14 | Swinton Lions | 18 | 1 | 1 | 16 | 310 | 637 | 48.66 | 8.33 |
Friday 2nd April 2021
Featherstone Rovers 28-18 Batley Bulldogs
Halifax Panthers 47-14 London Broncos
Saturday 3rd April 2021
York City Knights 6-21 Toulouse
Sunday 4th April 2021
Newcastle Thunder 30-30 Widnes Vikings
Sheffield Eagles 50-12 Bradford Bulls
Saturday 17th April 2021
Widnes Vikings 14-22 Dewsbury Rams
Sunday 18th April 2021
Swinton Lions 6-36 Featherstone Rovers
Whitehaven 29-20 Newcastle Thunder
Bradford Bulls 27-26 Halifax Panthers
York City Knights 14-20 Sheffield Eagles
Saturday 24th April 2021
Batley Bulldogs 48-16 Widnes Vikings
Sunday 25th April 2021
Swinton Lions 16-64 York City Knights
Featherstone Rovers 48-14 Whitehaven
Halifax Panthers 34-44 Toulouse
Newcastle Thunder 24-16 Sheffield Eagles
Bradford Bulls 35-14 Dewsbury Rams
Saturday 1st May 2021
Sheffield Eagles 20-20 London Broncos
Sunday 2nd May 2021
Newcastle Thunder 16-28 Batley Bulldogs
Whitehaven 22-30 Bradford Bulls
Widnes Vikings 46-10 Swinton Lions
Dewsbury Rams 20-30 York City Knights
Friday 7th May 2021
Sheffield Eagles 18-30 Batley Bulldogs
Saturday 8th May 2021
Sunday 9th May 2021
Swinton Lions 22-23 Bradford Bulls
London Broncos 50-30 Newcastle Thunder
Dewsbury Rams 0-36 Halifax Panthers
York City Knights 12-16 Featherstone Rovers
Saturday 15th May 2021
Batley Bulldogs 6-40 London Broncos
Saturday 16th May 2021
Halifax Panthers P-P Sheffield Eagles
Widnes Vikings 14-35 York City Knights
Monday 17th May 2021
Swinton Lions 18-20 Dewsbury Rams
Featherstone Rovers 68-0 Oldham
Saturday 22nd May 2021
Sunday 23rd May 2021
Dewsbury Rams P-P Batley Bulldogs
London Broncos 8-33 Bradford Bulls
Newcastle Thunder 0-32 Halifax Panthers
Widnes Vikings 44-6 Whitehaven
York City Knights 34-6 Oldham
Sheffield Eagles 18-50 Featherstone Rovers
Saturday 29th May 2021
Toulouse P-P Newcastle Thunder
Sunday 30th May 2021
Batley Bulldogs 26-12 Swinton Lions
Bradford Bulls 37-18 York City Knights
Halifax Panthers 8-16 Featherstone Rovers
London Broncos 30-10 Dewsbury Rams
Oldham 18-40 Widnes Vikings
Sheffield Eagles 25-25 Whitehaven
Sunday 6th June 2021
Bradford Bulls 31-12 Newcastle Thunder
Halifax Panthers 46-12 Sheffield Eagles
Saturday 12th June 2021
Oldham 28-32 Sheffield Eagles
Sunday 13th June 2021
Halifax Panthers 30-6 York City Knights
Dewsbury Rams 12-56 Toulouse
Swinton Lions 30-36 Newcastle Thunder
Whitehaven 20-24 Batley Bulldogs
Widnes Vikings 22-24 London Broncos
Featherstone Rovers 44-0 Bradford Bulls
Saturday 19th June 2021
Toulouse C-C Bradford Bulls
Sunday 20th June 2021
Dewsbury Rams 24-68 Featherstone Rovers
London Broncos 46-12 Whitehaven
Newcastle Thunder 40-6 Oldham
Swinton Lions 4-34 Halifax Panthers
York City Knights 20-22 Batley Bulldogs
Widnes Vikings 30-20 Sheffield Eagles
Saturday 26th June 2021
Featherstone Rovers 68-12 Newcastle Thunder
Sunday 27th June 2021
Batley Bulldogs 12-22 Halifax Panthers
Bradford Bulls 12-25 Widnes Vikings
London Broncos 38-24 Swinton Lions
Oldham 4-18 Dewsbury Rams
Whitehaven 37-12 York City Knights
Sheffield Eagles 6-54 Toulouse
Saturday 3rd July 2021
Toulouse C-C Oldham
Featherstone Rovers 63-14 London Broncos
Sunday 4th July 2021
Bradford Bulls 30-16 Batley Bulldogs
Dewsbury Rams 18-18 Sheffield Eagles
Whitehaven 36-22 Swinton Lions
York City Knights 26-28 Newcastle Thunder
Halifax Panthers 17-16 Widnes Vikings
Sunday 11th July 2021
Halifax Panthers 14-4 Whitehaven
Batley Bulldogs 12-32 Toulouse
London Broncos 50-20 York City Knights
Newcastle Thunder 24-12 Dewsbury Rams
Oldham 22-54 Bradford Bulls
Swinton Lions 22-30 Sheffield Eagles
Widnes Vikings 10-32 Featherstone Rovers
Thursday 15th July 2021
Dewsbury Rams 10-38 Batley Bulldogs
Saturday 17th July 2021
Toulouse C-C Newcastle Thunder
Saturday 24th July 2021
Toulouse C-C Dewsbury Rams
Sunday 25th July 2021
Sheffield Eagles 28-40 Halifax Panthers
Batley Bulldogs 42-12 Newcastle Thunder
Bradford Bulls 30-36 Featherstone Rovers
London Broncos C-C Widnes Vikings
Whitehaven 28-24 Oldham
York City Knights 46-10 Swinton Lions
Sunday 1st August 2021
Dewsbury Rams 18-22 Swinton Lions
Featherstone Rovers 6-23 Toulouse
Halifax Panthers 24-21 Bradford Bulls
Newcastle Thunder 14-20 Whitehaven
Oldham 20-30 London Broncos
Widnes Vikings 16-34 Batley Bulldogs
Sheffield Eagles P-P York City Knights
Sunday 8th August 2021
Batley Bulldogs 13-28 Featherstone Rovers
Bradford Bulls P-P Sheffield Eagles
Halifax Panthers 14-12 Newcastle Thunder
London Broncos 6-66 Toulouse
Swinton Lions 22-22 Oldham
Whitehaven 20-18 Dewsbury Rams
York City Knights 34-20 Widnes Vikings
Saturday 14th August 2021
Newcastle Thunder 12-36 Bradford Bulls
Featherstone Rovers 44-14 York City Knights
Toulouse C-C Halifax Panthers
Sunday 15th August 2021
Sheffield Eagles 25-18 Oldham
Swinton Lions 6-38 Batley Bulldogs
Whitehaven 32-18 London Broncos
Dewsbury Rams 23-22 Widnes Vikings
Sunday 22nd August 2021
Batley Bulldogs 56-12 Sheffield Eagles
Bradford Bulls 30-26 Swinton Lions
Featherstone Rovers 64-6 Dewsbury Rams
Newcastle Thunder P-P London Broncos
Oldham 6-34 Toulouse
Widnes Vikings 25-6 Halifax Panthers
York City Knights 30-12 Whitehaven
Saturday 28th August 2021
Toulouse C-C Batley Bulldogs
Sunday 29th August 2021
Dewsbury Rams v Newcastle Thunder
Halifax Panthers v Swinton Lions
London Broncos v Sheffield Eagles
Oldham v Featherstone Rovers
Whitehaven v Widnes Vikings
York City Knights v Bradford Bulls
Friday 3rd September 2021
Newcastle Thunder v York City Knights
Sunday 5th September 2021
Batley Bulldogs v Whitehaven
Bradford Bulls v Toulouse
Featherstone Rovers v Halifax Panthers
Sheffield Eagles v Dewsbury Rams
Swinton Lions v London Broncos
Widnes Vikings v Oldham
Saturday 11th September 2021
Toulouse v York City Knights
Sunday 12th September 2021
Batley Bulldogs v Dewsbury Rams
London Broncos v Featherstone Rovers
Oldham v Newcastle Thunder
Whitehaven v Halifax Panthers
Widnes Vikings v Bradford Bulls
Sheffield Eagles v Swinton Lions
Saturday 17th September 2021
Newcastle Thunder v Toulouse
Sunday 18th September 2021
Bradford Bulls v Whitehaven
Dewsbury Rams v Oldham
Featherstone Rovers v Sheffield Eagles
Halifax Panthers v Batley Bulldogs
Swinton Lions v Widnes Vikings
York City Knights v London Broncos